GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12107539 | 1 | rs4680307 | chr3:151000939 | GPR87 | chr3:151011876-151034636:- | 0.2 | 4.61 | 5.17E-6 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs12107539 | 1 | rs4680307 | chr3:151000939 | P2RY14 | chr3:150929905-150996230:- | -0.18 | -3.81 | 0.000156 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs12107539 | 1 | rs4680356 | chr3:151051100 | GPR87 | chr3:151011876-151034636:- | 0.19 | 4.22 | 2.95E-5 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs12107539 | 1 | rs4680356 | chr3:151051100 | P2RY14 | chr3:150929905-150996230:- | -0.21 | -4.5 | 8.58E-6 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs7616215 | 1 | rs4683184 | chr3:46187707 | CCR3 | chr3:46205096-46308162:+ | 0.2 | 3.98 | 7.96E-5 | Behcet's disease |
| THCA | cis | rs7616215 | 1 | rs4683184 | chr3:46187707 | FYCO1 | chr3:45959396-46037307:- | -0.13 | -3.72 | 0.000221 | Behcet's disease |
| THCA | cis | rs9815925 | 1 | rs4686792 | chr3:184552325 | C3orf70 | chr3:184795840-184870802:- | -0.26 | -5.02 | 7.19E-7 | Heschl's gyrus morphology |
| THCA | cis | rs9815925 | 1 | rs4686865 | chr3:184614436 | C3orf70 | chr3:184795840-184870802:- | -0.25 | -4.92 | 1.17E-6 | Heschl's gyrus morphology |
| THCA | cis | rs10937470 | 1 | rs4687207 | chr3:190998437 | UTS2D | chr3:190984945-191048325:- | 0.17 | 3.43 | 0.000646 | Total ventricular volume (Alzheimer's disease interaction) |
| THCA | cis | rs736408 | 1 | rs4687552 | chr3:52838402 | GLYCTK | chr3:52321836-52329271:+ | -0.17 | -3.69 | 0.000253 | Bipolar disorder |
| THCA | cis | rs736408 | 1 | rs4687552 | chr3:52838402 | ITIH4 | chr3:52847007-52866554:- | 0.23 | 6.1 | 2.18E-9 | Bipolar disorder |
| THCA | cis | rs736408 | 1 | rs4687552 | chr3:52838402 | NEK4 | chr3:52744803-52804951:- | -0.15 | -4.34 | 1.74E-5 | Bipolar disorder |
| THCA | cis | rs736408 | 1 | rs4687552 | chr3:52838402 | NT5DC2 | chr3:52558386-52569093:- | -0.29 | -6.27 | 7.92E-10 | Bipolar disorder |
| THCA | cis | rs736408 | 1 | rs4687552 | chr3:52838402 | PBRM1 | chr3:52579368-52719866:- | 0.16 | 5.53 | 5.3E-8 | Bipolar disorder |
| THCA | cis | rs736408 | 1 | rs4687552 | chr3:52838402 | RFT1 | chr3:53122503-53164470:- | -0.23 | -3.93 | 9.92E-5 | Bipolar disorder |